Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia
نویسندگان
چکیده
منابع مشابه
Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia
Fusion proteins composed of the histone methyltransferase mixed-lineage leukemia (MLL) and a variety of unrelated fusion partners are highly leukemogenic. Despite their prevalence, particularly in pediatric acute leukemia, many molecular details of their transforming mechanism are unknown. Here, we provide mechanistic insight into the function of MLL fusions, demonstrating that they capture a t...
متن کاملThe mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling.
AF4 gene, frequently translocated with mixed-lineage leukemia (MLL) in childhood acute leukemia, encodes a putative transcriptional activator of the AF4/LAF4/FMR2 (ALF) protein family previously implicated in lymphopoiesis and Purkinje cell function in the cerebellum. Here, we provide the first evidence for a direct role of AF4 in the regulation of transcriptional elongation by RNA polymerase I...
متن کاملClinical relevance of acute mixed-lineage leukemia.
A recent report by Pui et all focused on the biologic and clinical relevance of acute mixed-lineage leukemia; namely, acute lymphoblastic leukemia expressing myeloid-associated antigens (My+ ALL) and acute myeloid antigens expressing lymphoid antigens (Ly+ AML) were analyzed in a pediatric series. In our opinion, a major point in the field of hybrid acute leukemia remaining undetermined is whic...
متن کاملClinical Relevance of Acute Mixed-lineage Leukemia
A recent report by Pui et all focused on the biologic and clinical relevance of acute mixed-lineage leukemia; namely, acute lymphoblastic leukemia expressing myeloid-associated antigens (My+ ALL) and acute myeloid antigens expressing lymphoid antigens (Ly+ AML) were analyzed in a pediatric series. In our opinion, a major point in the field of hybrid acute leukemia remaining undetermined is whic...
متن کاملThe molecular biology of mixed lineage leukemia.
Mixed lineage leukemia is a very aggressive blood cancer that predominantly occurs in pediatric patients. In contrast to other types of childhood acute leukemias, mixed lineage leukemia presents with a dismal prognosis and despite the availability of advanced treatment methods cure rates have stagnated over the last years. Mixed lineage leukemia is characterized by the presence of MLL fusion pr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Biology
سال: 2009
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000249